timsTOF fleX MALDI-2

MALDI-2 increases sensitivity by up to 1-3 orders of magnitude depending on sample, analyte and matrix. MALDI-2 ionizes a wider range of chemical classes by reducing ion suppression effects, expanding chemical range for targeted analytes in MALDI Imaging.

After the initial MALDI process, a second laser, sitting parallel to the sample surface, fires into the evolving plume and post-ionizes neutral (mainly matrix) molecules. A charge transfer from post-ionized matrix molecules to neutral analyte molecules leads to an amazing sensitivity gain for many analytes.

MALDI-2 post-ionization compensates the lower sample amount per pixel, making even the finest molecular distributions visible. Combining MALDI-2 post-ionization with microGRID enabled high spatial resolution opens the field for the analysis of the smallest unit of eukaryotic life – single cells. This unique combination makes the timsTOF fleX MALDI-2 the platform of choice for out of the box single cell imaging.

No physical hardware changes are needed to activate post-ionization. By just one click in the software the user will be able to change between post-ionization and traditional MALDI mode. This is done in seconds and allows for direct comparison of the two different ionization processes.

fleXmatrix® for MALDI-2

Especially developed for use with the timsTOF fleX MALDI-2.

Able to remain stable under vacuum conditions.