timsTOF MALDI PharmaPulse®

timsTOF MPP adds a new dimension to HTS by utilizing, for the first time ever, Trapped Ion Mobility Spectrometry for ultrafast separation and CCS awareness.

TIMS is capable of separating isobars and even isomers on a timescale significantly faster than SPE (typically ≤ 1 sec per separation cycle) enabling interference-free quantitation of target compounds indistinguishable by mass spectrometry alone.

timsTOF MPP uses a dual MALDI/ESI ion source with industry-leading 10 kHz smartbeam™ 3D laser to enable uHTS compatible speed and throughput, and is available with the unique MALDI-2 option for an expanded chemical space.

Readout of a 1536 formatted sample plate in high-resolution MS or MS/MS mode takes less than 10 minutes, typically (reading rates up to 3 wells / sec).

The core of the solution is Bruker´s timsTOF mass spectrometer equipped with:

-Dual MALDI / ESI ion source

-Autoloader for MALDI plate exchange by robot

-MALDI-2 (optionally)

-Light-weight plate adapters ensure safe handling of MALDI plates by lab robotics during fully automated sample preparation and subsequent data acquisition campaigns.

-Cost-efficient disposable MALDI sample plates allow for automated MALDI preparation by high-performance liquid handlers in any format ranging from 96 to 1536 and beyond.

Label-free monitoring of enzyme activity is performed on the timsTOF MALDI PharmaPulse® at HTS speed and highest level of performance.