timsTOF

Ion mobility spectrometry (IMS) is a powerful analytical technique that has been widely applied over the last five decades, primarily in chemical physics and analytical chemistry applications. Only relatively recently has the potential of IMS coupled to MS (IMS-MS) been explored for the separation, identification and quantification of peptides and proteins.

TIMS Trapped Ion Mobility Spectrometry is an IMS separation technique in gas phase, which resolves sample complexity with an added dimension of separation in addition to HPLC and mass spectrometry, increasing peak capacity and confidence in compound characterization. Equally as important, the TIMS device also serves to accumulate and concentrate ions of a given mass and mobility, enabling a unique increase in sensitivity and speed along with the additional dimension of separation. By incorporating a TIMS device at the front of a quadrupole time-of-flight (QTOF) mass spectrometer, ions can be accumulated for a specific amount of time before being released for MS analysis.

timsTOF Applications:

–           Proteomics

–           MALDI imaging

–           Metabolomics

timsTOF instruments:

-timsMetabo

-timsOmni

-timsTOF flex

-timsTOF fleX MALDI-2

-timsTOF HT

-timsTOF MALDI PharmaPulse®

-timsTOF Pro 2

-timsTOF SCP

-timsUltra AIP